Predictive Value of TEG and CCT Related Parameters on Venous Thrombosis of Lower Limbs after Total Knee Arthroplasty

LI Xingjing; WANG Zhizhen; YAN Dongzhan

doi:10.3969/j.issn.1672-7185.2024.06.016

Abstract：Objective To explore the predictive value of TEG and CCT for venous thrombosis of lower limbs after total knee arthroplasty.Methods A total of 137 patients admitted to Liaocheng Second People's Hospital for total knee arthroplasty from June 2021 to June 2022 were selected as the study objects.Patients with venous thrombosis after total knee arthroplasty were classified as the venous thrombosis group(n=43),while those without venous thrombosis were classified as the non-venous thrombosis group(n=94).On the 3rd day after surgery,TEG and CCT were used to evaluate the coagulation function status of patients.The TEG and CCT related parameters were compared between two groups.The ROC curve were used to evaluated the diagnostic value of TEG and CCT related parameters in venous thrombosis after total knee replacement.The logistic regression was used to analyzed the factors affecting venous thrombosis in patients with total knee replacement.Results There were significant differences in α angle,maximum amplitude of trace,composite index of coagulation,activated partial thromboplastin time,prothrombin time and D-dimer between venous thrombosis group and non-venous thrombosis group(P<0.05).Regression analysis shows that,α angle,maximum amplitude of trace,composite coagulation index and D-dimer were the influencing factors for lower limb venous thrombosis in patients after total knee replacement(P<0.05).The area under ROC of maximum amplitude of trace,composite coagulation index,α Angle,D-dimer,prothrombin time and activated partial thromboplastin time were 0.931,0.882,0.831,0.713,0.628,and 0.599,respectively.The area under ROC of the maximum amplitude,composite coagulation index and α angle were significantly larger than D-dimer,prothrombin time and activated partial thromboplastin time(P<0.05).Conclusion TEG is more effective than CCT related parameters in diagnosing lower limb venous thrombosis after total knee arthroplasty.