The Improvement of Neurotransmitter,Hemorheology and Neurological Function in Patients with Vascular Dementia by the Combination of Butylphthalide and Nimergoline
WU Qiong
Abstract：Objective To explore the improvement of neurotransmitters,hemorheology,and neurological function in patients with vascular dementia(VaD)by adding butylphthalide and nimergoline on basic treatment.Methods Fifty VaD patients admitted to the Second Affiliated Hospital of Shenyang Medical College from January to December 2022 were randomly divided into a monotherapy group and a combination group,with 25 cases in each group.Both groups received basic treatment.The monotherapy group received nifedipine monotherapy to improve circulation,while the combination group used a dual drug of butylphthalide and nimergoline to improve circulation.After 3 months of treatment,the curative effects of the two groups were compared.Results After treatment,the levels of neurotransmitter indicators,such as acetylcholine,norepinephrine,dopamine,5-hydroxy tryptamine,and brain derived neurotrophic factor in the combination group were significantly higher than those in the monotherapy group(P<0.05).The levels of hemorheological indicators,such as plasma viscosity,low shear rate,middle shear rate,high shear rate,and hematocrit in the combination group were significantly lower than those in the monotherapy group(P<0.05).The scores of Montreal cognitive assessment and mini-mental state examination in the combination group were significantly higher than those of the monotherapy group(P<0.05).Conclusion The combination of butylphthalide and nimergoline in the treatment of VaD can further enhance brain tissue excitability and inhibitory neurotransmitter secretion levels,reduce blood viscosity,and improve neurological function.
Keywords：Vascular dementiaButylphthaleinNemergolinNeurotransmittersHemorheologyNeurological function
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 43-46 )