Efficacy of Celecoxib Combined with Transforaminal Endoscopic Spine System Technique in the Treatment of Elderly Patients with Degenerative Lumbar Disc Herniation
XIE Ruitang
DIAO Baixin
MO Sihuan
QIN Qiongyao
HUANG Chong
Abstract：Objective To observe the effect of celecoxib combined with transforaminal endoscopic spine system(TESSYS)technique in the treatment of elderly patients with degenerative lumbar disc herniation.Methods Eighty elderly patients with degenerative lumbar disc herniation admitted to Guigang Gangbei District People's Hospital from March 2021 to February 2023 were randomly divided into operation group and combination group,with 40 cases in each group.The operation group was treated with TESSYS technique,and the combination group was treated with celecoxib capsule after surgery.The lumbar mobility function,biomechanics of lumbar and dorsal extensor muscles and serum inflammatory markers before and after treatment were compared between two groups.Results Three months after surgery,the visual analogue scale and Oswestry dysfunction index scores in the combination group were significantly lower than those in the operation group,while the score of the Japanese Orthopedic Society was significantly higher than that of the operation group(P<0.05).The peak torque and power of the combination group were significantly higher than those of the operation group in the lumbar and dorsal extension state,while the lumbar and dorsal flexion extension ratio was significantly lower than that of the operation group(P<0.05).The levels of Interleukin-1 β,matrix metalloproteinase-3 and prostaglandin E2 in the combinationgroup were significantly lower than those in the operation group(P<0.05).Conclusion The combination of celecoxib and TESSYS technology in the treatment of elderly degenerative lumbar disc herniation can effectively alleviate pain,improve lumbar mobility and biomechanical properties of the lumbar extensor muscle group,and reduce serum inflammatory indicators.
Keywords：Degenerative Lumbar Disc HerniationCelecoxibTransforaminal Endoscopic Spine SystemSerological Indicators
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 16-19 )