The Diagnostic and Predictive Effects of Magnetic Resonance Imaging(MRI)and Cognitive Function Indicators in Bipolar Disorder

LIANG Zhifeng

doi:10.3969/j.issn.1672-7185.2024.01.007

Abstract：Objective To exploring the diagnostic and predictive effects of magnetic resonance imaging(MRI)imaging and cognitive function indicators in bipolar disorder.Methods A total of 65 patients with bipolar disorder who were hospitalized or outpatient treated at the Third People's Hospital of Foshan from January 2020 to January 2023 were selected as the observation group,and 36 healthy individuals were selected as the control group through clinical volunteer recruitment.Both groups underwent MRI brain functional imaging to observe and compare the amplitude of low-frequency fluctuations(ALFF)and regional homogeneity(ReHo)values in different brain regions.Observe and compare the scores of the repeatable battery for the assessment of neuropsychological status(RBANS),the Hamilton anxiety scale(HAMA),the Hamilton depression scale(HAMD),the Bech-rafaelsen mania rating scale(BRMS)and the social disability screening schedule(SDSS)between two groups.Use logistic regression to analyze the correlation between various indicators and the occurrence of bipolar disorder.The area under the receiver operating characteristic curve(AUROC)was used to assess the predictive value of each indicator for the occurrence of bipolar disorder.Results The RBANS score of the observation group was significantly lower than that of the control group,while the HAMA,HAMD,BRMS,and SDSS scores were all significantly higher than those of the control group(P<0.05).The ALFF values in the medial superior frontal gyrus(right)and thalamus(left)of the observation group were significantly higher than those in the control group,the ReHo values in the medial superior frontal gyrus(right),thalamus(left),and superior temporal gyrus(right)were significantly higher than those in the control group,the ALFF values in the parahippocampal gyrus(right),lingual gyrus(right),and middle temporal gyrus(right)were significantly lower than those in the control group,the ReHo values in the orbital superior frontal gyrus(right)and posterior cingulate gyrus(right)were significantly lower than those in the control group(P<0.05).The logistic regression results showed that low ALFF values in the parahippocampal gyrus(right),high ALFF values in the thalamus(left),low ReHo values in the orbitofrontal gyrus(right),high ReHo values in the medial superior frontal gyrus(right),and low ReHo values in the posterior cingulate gyrus(right)are associated with the occurrence of bipolar disorder.The AUROC shows that the parahippocampal gyrus(right)ALFF value,thalamic gyrus(left)ALFF value,orbitofrontal gyrus(right)ReHo value,medial superior frontal gyrus(right)ReHo value,and posterior cingulate gyrus(right)ReHo value all have high sensitivity and specificity in predicting the occurrence of bipolar disorder,and the combined prediction of all indicators has an AUC value of 0.860,a sensitivity of 0.738,and a specificity of 0.833.Conclusion In addition to obvious symptoms of anxiety,depression,and mania,patients with bipolar disorder also have impaired cognitive and social functions,and there is partial abnormal activation in their brain regions.Among them,the parahippocampal gyrus(right)ALFF value,thalamic(left)ALFF value,orbitofrontal gyrus(right)ReHo value,medial superior frontal gyrus(right)ReHo value,and posterior cingulate gyrus(right)ReHo value can be used to assist in predicting the occurrence of bipolar disorder.