Effect of Shengji Xiangpi Plaster Combined with Recombinant Human Epidermal Growth Factor in the Treatment of Venous Leg Ulcers

WANG Haiqing

doi:10.3969/j.issn.1672-7185.2024.01.005

Abstract：Objective To explore the clinical efficacy of Shengji Xiangpi Plaster combined with recombinant human epidermal growth factor in the treatment of venous leg ulcers(VLU).Methods A total of 80 patients with VLU admitted to Xuzhou Hospital of Traditional Chinese Medicine from June 2016 to July 2023 were selected as the study subjects.They were randomly divided into a combination group treated with Shengji Xiangpi Plaster combined with recombinant human epidermal growth factor,and a control group treated with recombinant human epidermal growth factor,with 40 cases in each group.Compare the efficacy,wound healing time,and incidence of adverse reactions,as well as the wound area,serum inflammatory factor levels,quality of life before and after treatment between two groups.Results After treatment,the wound area,serum inflammatory factor levels,and the scores of quality of life in both groups improved compared to before treatment,and the combination group was significantly better than the control group(P<0.05).The total clinical effective rate of the combination group was significantly higher than that of the control group(P<0.05).The wound healing time of the combined group was significantly shorter than that of the control group(P<0.05).Both groups did not experience significant adverse reactions.Conclusion The combination of Shengji Xiangpi Plaster and recombinant human epidermal growth factor in the treatment of VLU has a better therapeutic effect than using recombinant human epidermal growth factor alone,and can reduce inflammatory reactions,improve quality of life,and have higher safety.