The Expression of Cytokeratin 19,Galectin-3,and Mesothelial Surface Microvilli Antigen in Papillary Thyroid Cancer Tissue and Their Correlation with Clinical Pathological Features and Prognosis
SHEN Xin
Abstract：Objective To investigate the expression of cytokeratin 19(CK19),galactose agglutinin 3(Galectin-3),and mesothelial surface microvilli antigen(MC)in papillary thyroid cancer tissue and their correlation with clinical pathological characteristics and prognosis.Methods A total of 122 patients with papillary thyroid cancer admitted to the First People's Hospital of Zunyi City from January 2019 to January 2020 were selected as the subjects.Thyroid papillary cancer tissue and adjacent normal tissue were collected from each patient.Immunohistochemical methods were used to detect the positive rates and expression levels of CK19,Gal-3,and MC in paired tissue samples.The relationship between CK19,Gal-3,MC and the clinical-pathological characteristics,prognosis of papillary thyroid cancer were analyzed.Results The positive expression rates of CK19,Gal-3,and MC in papillary thyroid cancer tissue were significantly higher than those in adjacent normal tissue,(P<0.05).There were significant differences in the expression rates of CK19,Gal-3,and MC indifferent stages,differentiation levels,and lymph node metastasis(P<0.05).After 3 years of follow-up after surgery,the recurrence rate of CK19,Gal-3,and MC positive expression groups was significantly higher than that of the negative expression group(P<0.05).Conclusion CK19,Gal-3,and MC are highly expressed in papillary thyroid carcinoma,which may play a synergistic role in tumor infiltration and metastasis,and are closely related to prognosis.
Keywords：Thyroid Papillary CarcinomaCytokeratin 19Galactose Agglutinin 3Mesothelial Surface Microvilli AntigenClinical Pathological CharacteristicsPrognostic Effects
Publication Date：2023-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 72-75,79 )