Clinical Study of Methylprednisolone Combined with Levetiracetam in the Treatment of Children Electrical Status Epilepticus during Sleep

CAI Huiqiang1; ZHANG Duanxiu2

doi:10.3969/j.issn.1672-7185.2020.06.009

Abstract：Objective To explore the value of methylprednisolone combined with levetiracetam in the treatment of children with epilepsy electrical status (ESES) during sleep. Methods 86 cases of ESES children treated in our hospital from February 2013 to March 2019 were selected as the research objects, and the random number table method was used to divide them into a reference group (n=43 cases) and an observation group(n=43 cases). The control group was treated with levetiracetam, the observation group with methylprednisolone and levetiracetam. The reference group was given oral levetiracetam, and the observation group was given methylprednisolone combined with levetiracetam. Observe and compare the intelligence test scores, clinical efficacy, EEG changes, and adverse reactions after 6 months of treatment in the two groups. Results After 6 months of treatment, the total effective rate of clinical treatment in the observation group (90.70%) was higher than that in the reference group (74.42%) (P<0.05); The total effective rate of EEG changes in the observation group (83.72%) was higher than that in the reference group (55.81%) (P<0.05); After 6 months of treatment, the IQ score, PIQ score and FIQ score of the two groups were higher than before treatment, and the observation group was significantly higher than the reference group (P<0.05); The incidence of adverse reactions in the observation group (13.95%) was slightly higher than that in the reference group (6.98%), but the difference was not statistically significant (P>0.05); The symptoms of adverse reactions were mild in both groups and disappeared after stopping the drug. Conclusion Methylprednisolone combined with levetiracetam in the treatment of ESES in children can effectively improve clinical symptoms and EEG performance, and improve the child's intelligence level. Although the adverse reactions slightly increased, it disappeared after stopping the drug and the safety was higher.