Relationship Between Oxidative Stress Level and Anticoagulation Function in Patients with Traumatic Fracture

WU Honglin

doi:10.3969/j.issn.1672-7185.2019.12.023

Abstract：Objective? To investigate the relationship between oxidative stress and anticoagulation function in patients with traumatic fracture. Methods? A total of 121 patients with traumatic fracture admitted to our hospital from 2018 to 2019 were divided into single fracture group (86 cases) and multiple fracture group (35 cases). Another 49 healthy people in the same period were selected as control group. The differences of oxidative stress index [superoxide dismutase (SOD), malondialdehyde (MDA)] and anticoagulant function index [partial thrombin time (APTT), prothrombin time (PT), fibrinogen (FIB), platelet count (PLT), mean platelet volume (MPV), platelet-large cell ratio (P-LCR) were observed. Results? There were significant differences in SOD and MDA levels among the three groups (P<0.05). There were significant differences in APTT, PT, FIB, PLT, MPV and P-LCR levels among the three groups (P<0.05). SOD was positively correlated with APTT and PT (P<0.05), but negatively correlated with FIB, PLT, MPV and P-LCR (P<0.05). MDA was negatively correlated with APTT and PT (P<0.05), but positively correlated with FIB, PLT, MPV and P-LCR (P<0.05). Conclusion? There is an imbalance between oxidation and antioxidant function in patients with fracture, that is, the level of oxidative stress increases, which is closely related to the condition of fracture.