Analysis of Cardiac Structure Function and Serum Hypoxia Inducible Factor-1alpha Level in Patients with Obstructive Sleep Apnea Hypopnea Syndrome
CHEN Ping
GONG Jing
LI Tiezhi
Abstract：Objective? To analyze the effect of obstructive sleep apnea hypopnea syndrome on cardiac structure function and serum hypoxia inducible factor-1alpha level in patients with obstructive sleep apnea hypopnea syndrome. Methods A total of 86 patients with obstructive sleep apnea hypopnea syndrome were selected from the otolaryngology department,The 4th People’s Hospital of Shenyang, from January 2017 to December 2018 as observation group. The healthy people were selected as the control group in the same period. Fasting peripheral venous blood was collected and the level of hypoxia inducible factor-1alpha was detected by enzyme-linked immunosorbent assay(ELISA). Cardiac structural and functional indexes of the two groups were compared by echocardiography. Results The level of serum hypoxia inducible factor-1alpha in the observation group was significantly higher than that in the control group, the thickness of ventricular septum and posterior wall of left ventricle were significantly thicker than those in the control group, and the left ventricular ejection fraction was significantly lower than that in the control group( P<0.05). Conclusion In patients with obstructive sleep apnea hypopnea syndrome, the serum level of hypoxia inducible factor-1alpha is increased, and the cardiac structure and function are affected. Clinical intervention measures should be taken actively to reduce the occurrence of adverse cardiac events.
Keywords：Obstructive Sleep Apnea Hypopnea SyndromeCardiac Structure FunctionSerum Hypoxia Inducing Factor-1alpha
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 39-41 )