Study on the Correlation between Serum Cystatin C Level and Cognitive Impairment in Patients with Acute Massive Cerebral Infarction in ICU
LI Xin
Abstract：Objective? To investigate the relationship between cystatin C (Cys C) level and cognitive impairment (CI) after acute massive cerebral infarction (AMCI). Methods? A total of 137 AMCI patients admitted to our hospital from 2017 to 2019 were retrospectively collected. According to the results of the Montreal Cognitive Function Assessment Scale (MoCA), all patients were divided into CI group (N=49 patients) and non-CI group (N=88 patients). The clinical data and Cys C test results of the two groups were compared. The correlation between Cys C level and MoCA score was analyzed. The related factors of CI were analyzed by Logistic multivariate regression method. Results? There were significant differences in diabetes mellitus complication, hypertension complication, creatinine, urea nitrogen and glomerular filtration rate between the two groups (P<0.05). Cys C level was negatively correlated with MoCA score (P<0.05). The levels of diabetes mellitus, creatinine, glomerular filtration and Cys C were closely related to the occurrence of CI (P<0.05). Conclusion? Cys C is a risk factor for CI after AMCI, that is, the higher the level of Cys C, the more serious CI is. It can be considered as one of the indicators for predicting CI in clinic.
Keywords：Cerebral InfarctionLarge AreaAcuteCystatin CCognitive ImpairmentIntensive Care Unit
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 72-74 )