Effect of Methylprednisolone Pulse Therapy on Severe Abdominal Allergic Purpura in Children

XIANG Lu

doi:10.3969/j.issn.1672-7185.2019.10.024

Abstract：Objective? To study the clinical effect of methylprednisolone pulse therapy on severe abdominal allergic purpura (HSP). Methods? A total of 92 children with severe abdominal HSP admitted to our hospital from January 2016 to January 2019 were randomly divided into observation group and control group, with 46 cases in each group. Both groups received hormone therapy on the basis of routine treatment, while the control group received prednisone orally after high-dose methylprednisolone pulse therapy, while the observation group received a decreasing dose of methylprednisolone pulse therapy, and then changed to prednisone orally. The symptoms, immune index improvement and adverse reaction rates of the two groups were compared. Results? The time of rash subsidence, abdominal pain relief, occult blood turning negative, joint pain disappearance and renal function recovery in the observation group were significantly shorter than those in the control group (P<0.05). After treatment, IgG in the two groups showed an significant upward trendencycompared with pre-treatment (P<0.05), but there was no significant difference between the two groups (P>0.05). IgA, C3, IL-6, IL-8, and TNF-alpha after post-treatment showed a significantly downward trendencycompared with pre-treatment (P<0.05), and there was significant difference between observation group and control group (P<0.05). The incidence of adverse reactions was 8.70% in the control group and 13.04% in the observation group, with no significant difference (P>0.05). Conclusion? Methylprednisolone pulse therapy for severe abdominal HSP can quickly relieve clinical symptoms and immune status, and has no significant increase in adverse reactions, which is worthy of clinical application.