Effect of Different Doses of Sodium Ferulate in the Treatment of Knee Osteoarthritis

WU Honglin

doi:10.3969/j.issn.1672-7185.2019.06.020

Abstract：Objective? To observe the clinical effect of different doses of sodium ferulate intra-articular injection on knee osteoarthritis (KOA). Methods A total of 160 patients with KOA admitted to our hospital from 2015 to 2018 were randomly divided into control group, low dose group, medium dose group and high dose group, 40 cases in each group. The control group was treated with sodium hyaluronate injection into the articular cavity of the knee joint, 20 mg/time. The other treatment groups were treated with sodium ferulate injection on the basis of the control group, dosage at 25 mg/time, 50 mg/time and 75 mg/time, respectively; once a week, the treatment course was 5 weeks. The levels of superoxide dismutase (SOD), malondialdehyde (MDA) and tumor necrosis alpha (TNF-alpha), and Lequesne score of knee joint function were compared before and after treatment. Results There was no significant differences in SOD, MDA, TNF-alpha and Lequesne scores before treatment in all groups (P>0.05). After treatment, SOD showed an upward trend, while MDA, TNF-alpha and Lequesne scores showed a downward trend. There were significant differences among the intra-groups (P<0.05). The indexes of middle dose group and high dose group were significantly better than those of low dose group and control group (P<0.05); there was no statistical differences between middle dose group and high dose group, and between low dose group and control group (P>0.05). Conclusion The sodium hyaluronate, combined with intra-articular injection of sodium ferulate for KOA is effective and dose-dependent.