Observation of the Efficacy of Butylphthalide Combined with Donepezil in the Treatment of Alzheimer’s Disease
NIE Zhenzhou
Abstract：Objective? To observe the clinical effect of butylphthalide combined with donepezil in the treatment of Alzheimer’s disease (AD). Methods A total of 119 AD patients admitted to Dandong Central Hospital from 2015 to 2018 were randomly divided into control group (59 cases) and observation group (60 cases). The control group was given donepezil tablets orally, while the observation group was given butylphthalide capsules on the basis of donepezil tablets. Both grous were treated for six months. The AD scale and vascular endothelial function were compared between the two groups after treatment. Results There was no significant differences in AD related scale scores and vascular endothelial function indexes between the two groups before treatment (P>0.05); after treatment, all aboved indexes were improved significantly (P<0.05). Conclusion Butylphthalide combined with donepezil can significantly improve the mental status, daily living function, cognitive function and vascular endothelial function for AD patients, which is better than single drug treatment, and is worthy of clinical application.
Keywords：Alzhemers DiseaseDementiaButylphthalideDonepezil
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 71-73 )