Distribution and Antibacterial Resistance of Pathogens in Pediatric Intensive Care Unit

ZHANG Nan; LIU Lin; CHU Yi

doi:10.3969/j.issn.1672-7185.2018.11.023

Abstract：Objective The aim of the study was to analyze the distribution and antibiotics resistance of pathogens in Pediatric Intensive Care Unit (PICU), and to instruct clinical reasonable application of antibiotics. Methods A retrospective analysis of infected children treated at PICU of Dalian Children's Hospitall between Jan. 2015 and Dec. 2016 was carried out to analyze the bacterial distribution and antibiotics resistance. Results A total of 348 pathogenic strains were isolated from 222 cases, including 188 strains of Gram-negative bacilli, 121 strains of Gram-positive cocci and 37 strains of fungus. The strains were isolated from sputum, blood and urine. The most common strains were Klebsiella pneumoniae, Escherichia coli, coagulase negative Staphylococcus, Pseudomonas aeruginosa and Acinetobacter baumannii. The mezlocillin and ceftriaxone resistant rates in maingram-negative bacteria were more than 40%, cefoperazone/sulbactam resistant rates were lower. There were no drug resistant strains founded in Escherichia coli and Acinetobacter baumannii. The penicillin and erythromycin resistant rates of staphylococcus were more than 80%, but no bacterial strain was founded to be resistance to vancomycin and teicoplanin. No drug resistant strains were founded in Fungus. Conclusion Gram-negative bacilli is the major pathogens in PICU in our hospital. There is an increasing tendency of fungal infection. At present, the drug resistance of pathogens is serious. Therefore, the monitoring of pathogenic bacteria in PICU and the analysis of its drug resistance have great guiding significance for antibiotics rational use in clinical practice.