Levels of Inlfammatory Cytokines in Peripheral Blood of Children with Mycoplasma Pneumonia at Different Stages

CHEN Xiaogeng; WEI Jiemiao; YAN Hong

doi:10.3969/j.issn.1672-7185.2017.01.023

Abstract：Objective To analyze the levels of inflammatory cytokines in peripheral blood of children with mycoplasma pneumonia at different stages.MethodsTwenty-four children with mycoplasma pneumonia were chosen from the outpatients and inpatients of Shenyang Children’s Hospital from January to December in 2015. Their levels of proinlfammatory cytokines (IL-1 β, IL-6 and TNF-α) and anti-inlfammatory cytokines (IL-2, IL-4 and IL-10) of peripheral blood were tested in acute stage and recovery stage respectively, and the results were compared with that of 21 children who were healthy according to the physical examination results of the same period (control group). ResultsThe difference between the expression levels of inlfammatory cytokines in peripheral blood of children with mycoplasma pneumonia at different stages and that of healthy children was obvious. The expression intensity of proinlfammatory cytokines such as IL-1β, IL-6 and TNF-α in children in acute stage was higher than that of the children in recovery stage and the control group, while the levels of anti-inlfammatory cytokines such as IL-2, IL-4 and IL-10 in children in acute stage were lower than that of the children in the recovery stage and that of the control group. The differences were of statistical signiifcance (P < 0.05).ConclusionThe imbalance of the expression of proinlfammatory cytokines and anti-inlfammatory cytokines in peripheral blood of children with acute mycoplasma pneumonia is detected. These indexes can be applied to evaluate of the state and stage of children patients, and can help to guide the treatment and assess the curative effect, which has certain clinical signiifcance.