Dexmedetomidine Combined with Granisetron in Preventing Postoperative Nausea and Vomiting after Gynecological Laparoscopic Surgery

Liu Xiaojie; Luo Furong; Feng Baoying

doi:10.3969/j.issn.1672-7185.2014.15.025

Abstract：ObjectiveTo investigate the effect of dexmedetomidine combined with granisetron in preventing postoperative nausea and vomiting after gynecological laparoscopic surgery. Methods 60 patients underwent gynecological laparoscopic surgery were randomly divided into the induction group(Ⅰ group, 20 cases), the end of surgery group(EOS group, 20 cases), and the granisetron group(G group, 20 cases). Dexmedetomidine was administered 10 min before induction in theⅠ group patients, or 30 min before the end of surgery in the EOS group patients. All patients received 3 mg of granisetron 30 min before the end of surgery. The time to extubation and response to verbal command, respiratory depression, dysphoria in the postanesthesia intensive care unit, incidence and severity of nausea and vomiting for postoperative 24 h were recorded.ResultsThe time to extubation and response to verbal command, nausea and vomiting scores in postoperative 0~1 h and 1~2 h, antiemetics given in the postanesthesia intensive care unit in theⅠ group were less than those in the EOS group and the G group(P<0.05). Nausea and vomiting scores within postoperative 0~1 h and 1~2 h, antiemetics given in the postanesthesia intensive care unit in the EOS group were less than those in the G group(P<0.05). Time to extubation and response to verbal command between the EOS group and the G group had no signiifcant difference(P>0.05); The nausea and vomiting scores of the three groups within postoperative 2~4 h, 4~12 h, and 12~24 h had no signiifcant difference(P>0.05).ConclusionDexmedetomidine combined with granisetron in preventing postoperative nausea and vomiting after gynecological laparoscopic surgery was more effective than using granisetron lonely, and it’s better by administered 10 min before induction.