The Optimal Dose in the Treatment of Neuropsychiatric Systemic Lupus Erythematosus by Intrathecal Injection with Methotrexate and Dexamethasone
Liang Xianzhang
Abstract：Objective To discuss the optimal dose in the treatment of neuropsychiatric systemic lupus erythematosus by intrathecal injection with methotrexate and dexamethasone. Methods 64 cases with neuropsychiatric systemic lupus erythematosus were collected, and divided into the control group, the high dose group, the medium dose group, and the low dose group with 16 cases of each group randomly. The control group accepted glucocorticoid routinely, based on that each observation group accepted intrathecal injection with methotrexate and dexamethasone by different doses. Then we compared the erythrocyte sedimentation rate, the cerebrospinal pressure, the protein, and the clinical manifestation in each group according to the treatment. Results After the treatment, all the observed indicators above were improved signiifcantly(P<0.05). Most of the observed indicators were improved more obviously than the control group(P<0.05), and the high dose group were improved obviously. Conclusion For the treatment of neuropsychiatric systemic lupus erythematosus, we recommend that the optimal dose of methotrexate and dexamethasone by intrathecal injection were all 20 mg, based on the using of glucocorticoid routinely.
Keywords：neuropsychiatric systemic lupus erythematosustreatmentmethotrexatedexamethasoneintrathecal injectiondose
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 42-43 )