Research progress on comprehensive treatment of hepatocellular carcinoma
ZHANG Wei-zhi
LIU Lian-xin
Abstract：Hepatocellular carcinoma(HCC)is one of the major malignancies under intensive control efforts in China,with a five-year survival rate remains to be improved.Early diagnosis and stage-guided comprehensive management are key measures to improve prognosis.For early-stage patients,curative surgery remains the primary approach to achieving long-term survival,while postoperative adjuvant therapies are increasingly moving toward precision and individualization.For intermediate and advanced stages,emphasis has shifted to conversion therapy and the combined use of locoregional and systemic treatments.In recent years,the rapid advancement of systemic therapies has significantly improved survival in advanced HCC and reshaped the therapeutic landscape.At present,treatment paradigm for advanced HCC has gradually evolved toward immunotherapy-based combination regimens.Overall,comprehensive management of HCC is trending toward"precision in locoregional therapy,earlier application of systemic therapy,and individualized full-course management".Within the multidisciplinary team framework,individualized strategies that integrate tumor stage,molecular characteristics,and patient condition are of critical importance for further improving survival outcomes.
Keywords：hepatocellular carcinomasurvivalcomprehen-sive treatmentimmunotherapytargeted therapymulti-disci-plinary team
Publication Date：2025-10-01
Online Publishing Date：2025-12-09(First online date of this platform, not the publication date of the document)
Pages：5( 1186-1190 )