The value of dynamic monitoring of calcitonin and carcinoembryonic antigen in clinical decision-making and whole-course management of medullary thyroid carcinoma
LI Chang-lin
SUN Hui
Abstract：The whole-course management of medullary thyroid carcinoma(MTC)relies heavily on dynamic monitoring of serum calcitonin(Ctn)and carcinoembryonic antigen(CEA).During the diagnostic and therapeutic stages,a comprehensive strategy of"Ctn as the primary indicator,CEA as a complementary marker,with imaging and genetic testing as supplements"should be established,providing crucial evidence for determining the extent of surgery,assessing metastatic risk,and guiding individualized interventions.In postoperative follow-up,patients with a Ctn doubling time(DT)of less than 6 months have a 10-year survival rate of only approximately 25％,while a shortened CEA DT indicates an increased risk of visceral metastasis.The synergistic monitoring system of Ctn and CEA runs through the entire process of diagnosis,surgery,and prognostic management of MTC,and serves as a cornerstone for optimizing individualized therapeutic strategies.
Keywords：medullary thyroid carcinomacalcitonincarcino-embryonic antigendynamic monitoringclinical decision-makingwhole-course management
Publication Date：2025-09-01
Online Publishing Date：2025-10-22(First online date of this platform, not the publication date of the document)
Pages：5( 1012-1015,1031 )