The future of hepatobiliary surgery research:the path to digital transformation in the precision medicine era

XU Jia-hao; ZHOU Chen-yao; YANG Tian

doi:10.19538/j.cjps.issn1005-2208.2025.09.04

Abstract：Hepatobiliary surgery is undergoing a digital transformation guided by the principles of precision medicine.Artificial intelligence(AI)can be applied to predict postoperative complications,recurrence risk,and survival outcomes,thereby reshaping surgical planning and decision-making paradigms.Three-dimensional visualization and augmented reality technologies enable real-time navigation of anatomical structures,improving the precision and safety of complex surgical procedures.Big data analytics facilitate multicenter,long-term prognostic studies,providing evidence-based guidance for optimizing treatment strategies.Precision medicine integrates genomic features with anatomical factors to guide individualized determination of surgical extent and adjuvant therapy selection.Advances in xenogeneic liver transplantation have expanded the donor pool;however,the risks of cross-species infection and immune rejection require mitigation through gene-editing technologies and robust ethical oversight.Al-driven intraoperative navigation and robotic surgery challenge the traditional role of surgeons,while the"digital divide",insufficient data standardization,and lack of regulatory frameworks continue to hinder widespread implementation.Future research should rely on high-quality clinical trials to validate the efficacy of emerging technologies,establish standardized data-sharing frameworks across institutions,and,while promoting technological innovation,uphold the core humanistic values of surgery-including clinical judgment and patient safety-to ensure that digital transformation ultimately maximizes improvements in patient outcomes.