Study on the clinical influencing factors of gastroesophageal reflux disease after sleeve gastrectomy

TANG Xin; ZHOU Fu-qing; CHEN Yu-han; DOND Shi-liang; WANG Cun-chuan; DOND Zhi-yong

doi:10.19538/j.cjps.issn1005-2208.2025.02.17

Abstract：Objective To explore the clinical influencing factors of gastroesophageal reflux disease(GERD)after sleeve gastrectomy(SG).Methods Retrospectively analyze the medical records of patients who underwent SG at the First Affiliated Hospital of Jinan University from January 1,2022 to December 31,2023.Patients were divided into a reflux group and a normal group according to whether acid reflux occurred 3 months after surgery.The preoperative clinical indicators of the two groups were compared.Stepwise regression analysis and logistic regression analysis were used to explore the influencing factors leading to early GERD after SG.Results A total of 430 patients who underwent SG were included in this study,and 81 patients developed GERD 3 months after surgery,with an incidence of 18.8％.There was no significant difference in clinical indicators such as age,gender,weight,body mass index,and abdominal circumference between the normal group(n=349)and the reflux group(n=81)before surgery(P＞0.05);the proportion of Helicobacter pylori(Hp)infection in the reflux group was higher than that in the normal group,with a statistically significant difference(18.5％vs.8.0％,P=0.008).The results of multivariate logistic regression analysis showed that Hp infection was an independent risk factor for GERD 3 months after SG(OR=2.96,95％CI 1.44-5.92,P=0.001).Conclusions Hp infection is an independent risk factor for GERD after SG.Preoperative Hp infection examination and postoperative Hp eradication therapy have potential reference value for reducing the incidence of GERD after SG.