Selection of transformation treatment plans for stage Ⅳ gastric cancer in the era of immunotherapy
WANG Quan
LI Shuang
Abstract：The transformation therapy for stage Ⅳ gastric cancer has become a current research hotspot.For patients with advanced gastric cancer undergoing conversion therapy,RO resection surgery should be attempted;For tumor lesions that are difficult to cure after evaluation,it is recommended to continue drug treatment and avoid palliative resection of R1 or R2 as much as possible.For stage Ⅳ gastric cancer patients with combined peritoneal metastasis,in addition to systemic chemotherapy,the combination of intraperitoneal infusion chemotherapy and immunotherapy has also become a research focus.At present,most conclusions are mainly based on small sample retrospective studies,and some studies have not distinguished between conversion therapy and neoadjuvant therapy.Therefore,there is an urgent need for large-scale prospective randomized controlled trials to further validate.In addition,advanced gastric cancer has high heterogeneity and significant individual differences.The molecular pathological characteristics between primary and metastatic lesions vary,requiring a deep understanding of epigenetics,genomics,and proteomics information in gastric cancer to guide individualized treatment for patients.
Keywords：gastric cancerconversion therapyintraperitone-al infusionimmunotherapy
Publication Date：2024-10-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1129-1133 )