Reasonable selection of surgical range and functional preservation for gastric cancer in the era of immunotherapy
ZHAO En-hao
CAO Hui
Abstract：With the advent of the era of immunotherapy,perioperative treatment of locally advanced gastric cancer using immunotherapy combined with chemotherapy has gradually changed from exploratory attempts to relevant clinical trials,and certain results have been achieved.Although the clinical trials at this stage have not obtained positive results in terms of long-term survival,the effects on pathological response and downstaging have been fully reflected.Therefore,whether the radical principles of primary lesion resection and regional lymph node dissection in traditional gastric cancer surgery can be challenged is more thought-causing.Appropriate patients were selected through accurate preoperative diagnosis,and on the basis of accurate identification of metastatic lymph nodes,primary lesion resection and accurate metastatic lymph node dissection or regional lymph node dissection were performed,so as to save more uninvolved lymph nodes to maintain T cell activity and specific killing function against tumor cells,and optimize the surgical approach and preserve the anatomical and physiological functions of the stomach to the greatest extent.Under the premise of ensuring the oncological safety,better improve the quality of life of patients.
Keywords：gastric cancerneoadjuvant therapyimmunotherapylymph node dissectionfunctional preservation
Publication Date：2024-10-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1125-1129 )