Effects of the multidisciplinary team on the prognosis of patients undergoing surgical treatment for retroperitoneal liposarcoma:a propensity score-matched retrospective cohort study
ZHU Tao
JIANG Quan
WANG Jiong-yuan
DING Yu-qin
WANG Bin-liang
YANG Yu
WANG Yi-chao
ZHANG Li
HOU Ying-yong
TONG Han-xing
ZHANG Yong
ZHOU Yu-hong
LU Wei-qi
Abstract：Objective To investigate the effect of a multidisciplinary team(MDT)model on the prognosis of patients with retroperitoneal liposarcoma(RLPS).Methods The clinical and pathological data of patients with RLPS treated at the Department of Retroperitoneal Tumor and Soft Tissue Sarcoma Surgery of Zhongshan Hospital,Fudan University from January 2009 to December 2022 were retrospectively analyzed.210 patients participated in MDT discussions,and 375 patients did not.The two groups of patients were matched 1:1 by propensity score matching(PSM),and 208 cases were selected in the MDT group and the non-MDT group,respectively.The clinical data of the two groups were analyzed and compared.Results After PSM matching,there were no statistically significant differences in gender,age,tumor length,tumor number,tumor origin,or recurrence between the two groups(P＞0.05).The results of the multivariate Cox analysis after PSM showed that recurrent tumor,FNCLCC grade Ⅲ,and surgical R2 margin status were independent risk factors for overall survival(OS).Recurrent tumor,multiple lesions,FNCLCC grade Ⅲ,and surgical R2 margin status were independent risk factors for progression-free survival(PFS).Whether to participate in MDT was the independent protective factor for PFS(HR=0.663,95％CI 0.515-0.855,P=0.002)and OS(HR=0.614,95％CI 0.414-0.911,P=0.015).The OS rates at 1,3,and 5 years were 93.6％,78.9％,and 71.6％in the MDT group,and 91.7％,67.2％,and 60.7％in the non-MDT group,respectively.The PFS rates at 1,3,and 5 years were 78.2％,49.8％,and 35.5％in the MDT group,and 68.4％,38.9％,and 29.8％in the non-MDT group,respectively.The OS rate(P=0.017)and PFS rate(P=0.003)in the MDT group were higher than those in the non-MDT group.Conclusion MDT model may improve the outcomes of patients undergoing surgical treatment for RLPS,but the specific benefits may require individualized assessments.
Keywords：retroperitoneal liposarcomamultidisciplinary teamoverall survivalprogression-free survival
Publication Date：2024-08-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 916-921 )