Changes in surgical treatment strategies for low rectal cancer under the background of immunotherapy
ZHANG Wei
Abstract：Traditional surgery is the main method for rectal cancer treatment,and with the continuously deepening applica-tion of immunotherapy to the field of rectal cancer treatment,the way,the means,and even the concept of treating low rectal cancer are gradually evolving.For low rectal cancer patients with MSI-H/dMMR,immunotherapy has shown a high re-sponse rate and potential long-term efficacy.Although the re-sponse rate of immunotherapy in MSS/pMMR tumors is low,with the continuous deepening of research,including the com-bined application of radiotherapy,chemotherapy,targeted ther-apy,etc.,as well as the emergence of more sensitive drugs and biomarkers in the future,the efficacy of immunotherapy will continue to improve so that more patients can obtain tumor re-gression.These results will also affect the surgical strategy for low rectal cancer,ultimately achieving the reduction of surgi-cal trauma,the increased rate of anal preservation and organ preservation,and improved life quality and prognosis.Despite challenges,such as how to select a suitable population,how to accurately evaluate efficacy,the uncertainty in long-term effi-cacy,treatment resistance,and immunotherapy-related side ef-fects,immunotherapy still has a broad application prospect in the treatment of low rectal cancer and is expected to bring more personalized and effective treatment options for patients.
Keywords：low rectal cancerimmunotherapysurgery
Publication Date：2024-07-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 741-744 )