Clinical and pathological characteristics and prognostic analysis of low-grade mucinous tumors of the appendix
ZHANG Qi
TANG Dong
ZHOU Jia-jie
YU Wenhao
WANG Wei
WANG Liuhua
REN Jun
LIU Zhu
WANG Jie
SUN Longhe
ZHU Xiaodong
WANG Dao-rong
Abstract：Objective To explore the clinical,pathological,and prognostic characteristics of low-grade mucinous tumors of the appendix(LAMN).Methods The clinicopathological data of 58 cases of LAMN admitted to the Gastrointestinal Surgery Department of Northern Jiangsu People's Hospital affiliated to Yangzhou University from July 2013 to April 2023 were retrospectively analyzed.The patients were divided into the LAMN group(37 cases)and the LAMN+PMP group(21 cases)based on whether with the presence of peritoneal pseudomyxoma(PMP).The clinical,pathological,and prognostic characteristics of the two groups of patients were compared.Results Among the 58 LAMN patients,33 had initial clinical manifestations of abdominal pain,16 had appendiceal or pelvic masses during physical examination,and 9 were directly diagnosed as appendiceal tumors;12 patients underwent simple appendectomy,3 underwent appendectomy+peritoneal biopsy,22 underwent ileocecal resection+biopsy or combined organ resection,and 21 underwent right hemicolectomy+peritoneal biopsy or combined organ resection.One patient had a positive surgical margin after surgery,and no positive lymph nodes were found in the pathological examination of the ileocecal and right hemicolectomy patients.The median follow-up period after surgery was 34(3-119)months,with 2 cases lost to follow-up.During the follow-up period,5 patients were found to have recurrence,and there was no evidence of recurrence in patients with positive margins.The overall 3-year survival rates of both groups of patients were 100.0%.The 3-year progression-free survival rate of the LAMN group was higher than that of the LAMN+PMP group,and the difference was statistically significant(100%vs.76.2%,P<0.001).Conclusion CT or endoscopic examination of patients with abdominal pain suggests that a mass in the ileocecal region has certain diagnostic significance for LAMN.Extended radical surgery is not routinely recommended for LAMN surgery,and patients with positive surgical margins can be closely followed up.And the prognosis of LAMN is better than that of LAMN+PMP.
Keywords：low-grade appendiceal mucinous neoplasmsperitoneal pseudomyxomaappendectomyileocecal resectionright colectomy
Publication Date：2024-05-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 583-587,593 )