Comparison of short-term clinical efficacy and safety between biological and synthetic meshesin:a multicenter controlled study
DU Hua-dong
LIU Xiao-li
NIE Yu-sheng
HU Zhi-wei
MA Qiu-yue
GUAN Lei
ZHAO Min-xian
LI Hai-yun
MA Song-song
XIN Cheng-lin
LUO Ying
DU Xing
LI Ruo-fan
REN Shu-lin
WU Ji-xiang
TIAN Guang-jian
LIU Dian-gang
YIN Jie
WU Ji-min
YANG Hui-qi
Abstract：Objective To compare the short-term clinical efficacy and safety of biological versus synthetic meshes in laparoscopic esophageal hiatal hernia repair.Methods This multicenter controlled clinical trial involved 298 patients undergoing laparoscopic esophageal hiatal hernia repair from January 2020 to December 2022 in six centers,led by Beijing Chaoyang Hospital,Capital Medical University.Participants were divided into either the biological mesh group or the synthetic mesh group,with 149 patients in each.Follow-up data were collected at 6 and 12 months postoperatively via phone or clinic visits.Results No significant difference was observed in the recurrence rates at 12 months postoperatively between the two groups,with 2.2％(3/135)in the biological mesh group and 2.9％(4/137)in the synthetic mesh group(P=0.716).Additionally,no complications were observed during the follow-up period in either group.Regarding symptom improvement,preoperative symptom scores comparison showed no significant differences between the biological and synthetic patch groups in terms of burning sensation behind the sternum,acid reflux,belching,chest pain,early satiety,,and dysphagia(P＞0.05).Similarly,there was no significant difference in symptom improvement scores at 12 months post-surgery between the two groups(P＞0.05).Furthermore,comparisons of quality of life scores,including physical functioning,role physical,bodily pain,general health,vitality,social functioning,role emotional,mental health,and health change,before and 12 months after surgery,revealed no significant differences between the groups(P＞0.05).Conclusion In laparoscopic hiatal hernia repair,biological and synthetic meshes exhibit similar short-term recurrence rates,symptom improvement,and quality of life enhancements.
Keywords：esophageal hiatal hernialaparoscopybiological meshsynthetic meshclinical efficacysafety
Publication Date：2024-04-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 447-451 )