Clinical pathological analysis and prognostic factors evaluation of intraductal papillary neoplasm of the bile duct
ZHANG Chao-lei
JIN Jun-bin
DING Guo-ping
LIANG Xiao
WANG Guan-yu
XU Bin
CAO Li-ping
Abstract：Objective To investigate the clinical pathological features of intraductal papillary neoplasm of the bile duct(IPNB)and the risk factors affecting the survival of malignant patients.Methods The clinical pathological features and postoperative follow-up data of 33 IPNB patients admitted to Sir Run Run Shaw Hospital affiliated with Zhejiang University from January 2014 to December 2020 were retrospectively analyzed.The clinical pathological features of IPNB patients with different histological grades and anatomical types were compared,and the risk factors affecting the survival of malignant IPNB patients were analyzed.Results In comparison to the benign group,patients with malignant IPNB were older(P=0.050),had higher median levels of CA19-9(P=0.004),and were more likely to show intraductal masses on preoperative CT or MR imaging(P=0.027).There were also differences in the extent of surgical resection(P=0.008).The overall survival rate of patients with malignant IPNB was lower than that of the benign group(P=0.012).Differences were observed in preoperative abdominal pain symptoms among patients with intrahepatic,extrahepatic,and diffuse types of IPNB(P=0.013).Multivariate Cox regression analysis indicated that postoperative recurrence was an independent risk factor for poor prognosis in patients with malignant IPNB(P=0.013).Conclusion The modified anatomical classification can provide some guidance for the resection range of IPNB lesions.The prognosis of malignant IPNB patients is relatively poor,and postoperative recurrence is significantly associated with the poor prognosis of malignant IPNB patients.
Keywords：bile duct tumorpapillary tumorbenign tumormalignant tumorpathological classificationanatomical classificationprognosis
Publication Date：2024-02-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 216-223 )