Controversy and consensus on the clinical application of Fecal microbiota transplantation in surgery
QIN Huan-long
FANG Zhi-xun
CHEN Qi-yi
Abstract：Fecal microbiota transplantation(FMT)refers to the transplantation of functional microbiota from healthy human feces into the patient's intestines in a certain way,to regulate the balance of gut microbiota,rebuilding gut microbiota,and achieve the goal of preventing and treating internal and external intestinal diseases.In recent years,FMT treatment has expanded from recurrent Clostridioides difficile infection(rCDI)to inflammatory bowel disease(IBD),irritable bowel syndrome(IBS),chronic constipation,and other diseases.The field of FMT treatment has also extended from internal medicine and pediatrics to surgery.Multiple clinical studies have shown that the application of FMT during the perioperative period can improve the cure rate of surgical patients,reduce postoperative complications,and improve postoperative nutritional status and quality of life.However,due to the short duration of FMT surgical research and the lack of high-quality clinical studies with large samples,the methodology of FMT itself is complex and there are methodological issues such as donor selection,standardized treatment of fecal samples,and establishment of FMT transplantation pathways that need to be improved.Further research and discussion are needed on the specific treatment plan and efficacy of FMT applied in the perioperative period of surgery.
Keywords：fecal microbiota transplantationmicroecologyfeces
Publication Date：2024-02-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 159-163 )