Key updates and interpretation of the 2023 edition of the Bethesda System for Reporting Thyroid Cytopathology
ZHANG Fu-rong
ZHAO Qiu-yang
HUANG Tao
Abstract：The 2023 edition of Bethesda System for Reporting Thyroid Cytopathology corresponds to the 2022 World Health Organization classification of thyroid tumors.In comparison to the 2010 and 2017 versions,significant updates in terms of diagnostic grading,recommended management approaches,and the assessment for risk of malignancy,as well as supplement of molecular testing have been made in the 2023 edition of Bethesda System for Reporting Thyroid Cytopathology.Distinct molecular events driving the dedifferentiation process in thyroid cancer have been identified,affirming the significance of molecular testing.As molecular testing continues to enhance the diagnostic efficacy of thyroid cancer,its application in the diagnosis and treatment of thyroid cancer is gradually expanding,with some instances even influencing surgical decision-making.However,both single-gene and multi-gene molecular testing still have limitations.Therefore,the widespread applicability of molecular testing in clinical practice to guide surgical decisions requires further research.
Keywords：thyroid cancerBethesdapathological typemolecular testingsurgical approach
Publication Date：2024-02-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 139-143 )