A questionnaire-based investigation on the status of neoadjuvant therapy for early-stage HER2-positive breast cancer in 118 tertiary hospitals in China
XIN Ling
ZHOU Si-cheng
JIANG Ze-fei
LIU Yin-hua
Abstract：Objective To investigate the status of neoadjuvant therapy for early HER2-positive breast cancer in China.Methods A questionnaire-based survey was conducted to investigate the treatment of patients with breast cancer from January 1,2023 to June 30,2023.The investigation content included the qualification of pathological department,certification of HER2 test reagent,the number of early breast cancer cases,the number of HER2-positive breast cancer cases,the number of cases receiving neoadjuvant therapy with anti-HER2 therapy and the pathological result after neoadjuvant therapy.Results A total of 118 tertiary hospitals from 13 provinces participated in the investigation,including 99 general hospitals and 19 oncology hospitals.Among them,85 hospitals(72％)had both pathological department qualification and certificated HER2 test reagent approved by the National Medical Products Administration,and 33 hospitals(28％)failed to provide pathological department qualification or reagent certification.A total of 39014 cases of patients with early-stage breast cancer were admitted in 118 hospitals.9160(23.5％)cases were HER2-positive breast cancer.3222(35.2％)patients received neoadjuvant therapy with dual HER2-targeted regimen,with pCR rate of 51.3％.The pCR rate after neoadjuvant therapy with dual HER2-targeted regimen in hospitals with qualification was significantly higher than that those hospitals without certification(56.2％vs 48.0％,P=0.046).Conclusion To improve the qualification of pathological department and HER2 test certification is an important measure to achieve clinical homogenization of diagnosis and treatment for breast cancer.
Keywords：breast cancerHER2 positiveneoadjuvant therapypathological quality control
Publication Date：2024-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 98-102 )