Predictive value of ALBI score for early recurrence of hepatocellular carcinoma after liver resection

LING Shuai-bo; LI Lu-hao; LIU Zhao-chen; LI Su-xin; LI Lin; LIU Sheng-yan; DANG Xiao-wei

doi:10.19538/j.cjps.issn1005-2208.2023.12.18

Abstract：Objective To investigate the risk factors of early recurrence of hepatocellular carcinoma(HCC)after liver re-section,and to evaluate the value of ALBI score in predicting early recurrence of HCC after liver resection.Methods Clinical data of patients diagnosed with HCC combined with hepatectomy in the Department of Hepatopancreatobiliary Surgery,The First Affiliated Hospital of Zhengzhou University from January 2016 to December 2020 were retrospectively collected and divided into two groups according to whether they had recurrence within 2 years after surgery:early recur-rence group(n=63,recurrence within 2 years)and no early recurrence group(n=75,no recurrence within 2 years).The risk factors of early recurrence were analyzed.Kaplan-Meier method and Log-Rank test were used to compare the tumor-free survival rate of patients with different ALBI scores.Results There were significant differences in maximum tumor diam-eter,microvascular invasion,alkaline phosphatase,alpha-fetoprotein and ALBI scores between early recurrence group and non-early recurrence group(P＜0.05).Multivariate Logistic regression analysis showed tumor diameter(OR=2.201,95％CI 1.055-4.594,P=0.036),MVI(OR=2.425,95％CI 1.058-5.562,PP=0.036)and ALBI grade(OR=2.442,95％CI 1.130-5.279,P=0.023)are independent risk factors for early recurrence after HCC resection.There were differences in recur-rence at 6 months,1 year and 2 years after resection in different ALBI groups(P＜0.05).Kaplan-Meier recurrence-free survival curve showed that the recurrence risk in high-grade ALBI group was higher than that in low-grade ALBI group,and the difference was statistical-ly significant(P＜0.05).Conclusion ALBI score has a certain value in predicting early recurrence af-ter HCC resection,and can be used for risk stratification of postoperative recurrence in HCC patients.