Selection of liver resection and liver transplantation for patients with hepatocellular carcinoma
Abstract：Liver resection (LR) and liver transplantation (LT) are the main radically curative treatments for hepatocellular carcinoma (HCC) currently.For patient with HCC amenable for either treatment,there is still a controversy on selection of LR or LT for tumor at different stages,particularly at intermediate stage.Studies suggested that there was no difference in overall survival between both options for HCC patients within Milan criteria (MC),who were optimal candidates for a curative LR.For patients with severe cirrhosis and multiple tumors (≤3) within MC,LT achieved a better long-term survival.Although evidences of comparison of long-term outcomes following both treatments for intermediate HCC beyond MC is still insufficient,several MC-expanded criteria have been proposed,especially,from China,showing optimal accuracy in selecting transplant patients.However,LR+ salvage LT may be another therapeutic strategy worthy of discussion.A well-designed,prospective study which overcomes the selection biasis is urgently required to clarify the prognostic difference between the two treatments.
Keywords：hepatocellular carcinomaliver resectionliver transplantationMilan criteriasalvage liver transplantation
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 121-125 )