The progress and controversy on precision medicine of colorectal cancer
YAO Hong-wei
ZHANG Zhong-tao
Abstract：The main treatment of eolorectal cancer is still surgical and comprehensive treatment.The eighth edition of AJCC colorectal cancer staging,recommended MSI,KRAS,NRAS and BRAF testing with high level of "evidence-based medicine" evidence.The diagnosis and treatment of colorectal cancer has changed from the traditional population based care to personalized precision medicine.The traditional distinction of left-and right-sided colon cancer is based on anatomy,embryology and symptomatology.And based on molecular pathology and immune environment,the sideness of colon cancer has gained a new definition from the development of precision medicine,and become one of the key factors to consider how to choose the targeted therapy and prognosis evaluation.The consensus molecular subtypes of colorectal cancer has been published for several years,but it is still controversial how to give more specific clinical maneuverability.Precision medicine of colorectal cancer will re-plan the cancer classification,prevention and screening,diagnosis and treatment,outcome prediction,and prognosis evaluation.Surgeons should welcome the era of precision medicine for colorectal cancer.
Keywords：colorectal cancercancer stagingprecision medicineconsensus molecular subtypes
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 68-71 )