Comparison of the outcome of palliative therapy and endoscopic stenting in unresectable gastric cancer: A Meta-analysis
ZHANG Wen-jie
XU Hao
XU Ze-kuan
Abstract：Objective To evaluate the safety and feasibility of palliative gastrojejunostomy (GJJ) and endoscopic stenting (ES) for gastric outlet obstruction (GOO) caused by unresectable gastric cancer.Methods The literatures before August 2017 in Pubmed,Elsevier,SPRINGER,Cochrane Library,CNKI,CBM and Wanfang database were searched extensively to retrieve the comparative studies of palliative GJJ and ES in unresectable gastric cancer with a relevance of study goal.The inclusion and exclusion criteria were formulated.After a quality evaluation,the data were extracted.Meta-analysis was conducted by the Stata 12.0 software.Results A total of thirteen studies met the inclusion criteria for meta-analysis.Compared with ES,the GJJ group had a higher rate of clinical success (OR=2.271,95％CI 1.539-3.352,P＜0.001),lower re-obstruction rate (OR=0.351,95％CI 0.248-0.496,P＜0.001),longer patency duration (WMD=243.386,95％CI 152.309-388.925,P＜0.001).However,the ES group had a shorter procedure time (WMD=112.548,95％CI 90.272-140.320,P＜0.001),faster resumption of oral intake (WMD=6.121,95％CI 4.616-8.118),and shorter duration of hospital stay(WMD=14.208,95％CI 9.578-21.077,P＜0.001).Procedure-related mortality and complications were not significantly different between the ES group and GJJ group.Conclusion Both GJJ and ES are effective procedures for the treatment of GOO caused by gastric cancer.GJJ should be considered a treatment option for patients with a long life expectancy and good performance status.
Keywords：advanced gastric cancerpalliative gastrojejunostomyendoscopic stentingMeta-analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1143-1148 )