Case analysis of conversion therapy by laparoscopic HIPEC combined with intraperitoneal and systemic chemotherapy for gastric cancer peritoneal metastasis
Abstract：Objective To investigate the efficacy of laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) combined intraperitoneal and systemic chemotherapy in gastric cancer patients with peritoneal metastasis.Methods A gastric cancer patient whose peritoneal cancer index was 39 during laparoscopic exploration was admitted at Peking University Cancer Hospital Gastrointestinal Center.The patient received laparoscopic HIPEC with docetaxel,followed by 6 courses of intraperitoneal and intravenous PTX,along with S-1 orally.Results CT scan showed distinct response during post-treatment evaluation.A second look by laparoscopy was suggested by MDT.No tumor cell was found in the lavage fluid through abdominocentesis and no metastasis can be seen by laparoscopic exploration.Then total gastrectomy plus D2 minus No.10 lymph node dissection was performed.The patient recovered smoothly after surgery.The pathology confirmed a ypT3N2M1,moderate to poor-differentiated adenocarcinoma,from gastric antrum to body.By September 2017,the patient was still in postoperative treatment.Conclusion Laparoscopic HIPEC combined with intraperitoneal and systemic chemotherapy showed effective interim results in gastric cancer peritoneal metastasis conversion therapy and is deserved for further researches.
Keywords：gastric cancerperitoneal metastasishyperthermic intraperitoneal chemotherapyintraperitoneal chemotherapyconversion therapylaparoscopic surgery
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1135-1138 )