Role of neoadjuvant (chemo)-radiotherapy in local advanced gastric cancer
ZHANG Zhen
LI Gui-chao
Abstract：Considerable local regional recurrence and distant metastasis of locally advanced gastric cancer suggest that surgery alone maybe inadequate and further comprehensive treatment is expected to reduce recurrence and improve efficacy.For locally advanced gastric cancer,there is still a lot of debate about the optimal multidisciplinary treatment modalities,including surgery,radiation,and chemotherapy.At present,there are three main treatment modalities,including perioperative chemotherapy,postoperative chemotherapy and postoperative chemoradiotherapy.The neoadjuvant chemoradiotherapy model is mainly derived from the clinical data of the esophagogastric junction (EGJ) tumor,however,there is no randomized trial designed special for gastric cancer patients.Furthermore,for clinical trials,there are still many aspects that need attention,including accurate preoperative staging,selection of the appropriate cohort (locally advanced stage),standardization of upper digestive tract tumor site and selection of the appropriate parts of the tumor population,standardization of radiotherapy dosage and clinical target volume,select the appropriate chemotherapy and non-radiotherapy chemotherapy,choose appropriate therapeutic evaluation system,and suggestions to optimize the operation standard,meanwhile,we should pay attention to the assessment of nutritional status of patients and appropriate intervention.This overview discusses the role of neoadjuvant (chemo)-radiotherapy in the treatment of locally advanced gastric cancer and some relative aspects.
Keywords：locally advanced gastric cancerradiotherapyneoadjuvant chemoradiotherapy
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1109-1114 )