Analysis of perioperative factors affecting postoperative survival in patients with rectal cancer and establishment of PNAG score
Abstract：Objective To evaluate the relationship between clinicopathologic factors and perioperative inflammation and postoperative survival of rectal cancer.Methods The clinicopathologic data,perioperative inflammatory indicators and follow-up data were retrospectively collected from 382 consecutive patients diagnosed as stage Ⅰ to Ⅲ rectal caners at the Sixth Affiliated Hospital of Sun Yat-sen University from June 2007 to August 2012.Results The median follow-up time was 46 months.The 1-,3-and 5-year overall survival rates were 96.7％,85.6％ and 77.4％,respectively.The 1-,3-and 5-year disease free survival rates were 86.9％,72.0％ and 68.1％,respectively.Multivariate analysis found that age,pathologic TNM stages,gross types,vessel invasion and PNAG-score were independent prognostic factors for overall survival,while pathologic TNM stages,vessel invasion and PNAG-score were independent prognostic factors for disease free survival.Conclusion The postoperative survival of rectal cancer patients is influenced by both clinicopathologic risk factors and systemic inflammation.As a combined indicator of perioperative inflammation,PNAG-score shows an important role in survival assessment.
Keywords：rectal cancerperioperative periodsystemic inflammationsurvivalPNAG score
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 654-659 )