Optimal timing of surgery following neoadjuvant chemoradiotherapy in locally advanced rectal cancer
CAO Jian
YE Ying-jiang
WANG Shan
Abstract：The standard treatment for locally advanced rectal cancer (LARC) is curative surgical resection,combined with neoadjuvant chemoradiation therapy (nCRT) and additional adjuvant therapy if indicated.But the optimal interval between CRT and surgery is still unclear.Prolonging the interval to 12 weeks may lead to significantly higher rates of tumor downstaging and pathologic complete response (pCR).However,delayed surgery may increase the technical difficulty,and reduce the quality of surgery.Whether prolonged interval can improve long-term outcome is uncertain.Individualized treatment strategies should be based on the patient's condition.
Keywords：locally advanced rectal cancerneoadjuvant chemoradiotherapysurgeryoptimal time interval
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 637-640 )