Management of clinical complete response after neoadjuvant chemoradiotherapy in low rectal cancer
LUO Shuang-ling
KANG Liang
Abstract：Neoadjuvant chemoradiotherapy (CRT) followed radical surgery including total mesorectal excision (TME) is standard treatment in patients with locally advanced rectal cancer.The benefits of neoadjuvant CRT have been well documented and include tumor regression and downstaging associated with increased tumor respectability,reduced local recurrence and a higher rate of sphincter preservation.Radical surgery for rectal cancer carries a high risk of morbidity and mortality and can also greatly detract from a patient's quality of life.In light of the significant response rates that can be achieved with preoperative CRT,some scholars have suggested limiting further surgical therapy to local excision or just wait and see.Recently,several studies have explored the feasibility and efficacy of organ-preserving strategies for low rectal cancer.Therefore,it's a new challenge for clinician to choose how to treat the situation with clinical complete response after neoadjuvant therapy for low rectal cancer patients.
Keywords：rectal cancerneoadjuvant chemoradiotherapycomplete responsewait-and-seelocal excision
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 619-624 )