The treatment experience for a new set of multiple endocrine neoplasia type 1 family
LI Peng
ZHU Li-zhang
WEI Wei
Abstract：Objective To explore characteristics, diagnosis and treatment principles for the familial multiple endocrine neoplasia type 1 (MEN1). Methods The clinical manifestations, diagnosis, treatment and prognosis were analyzed for a group of familial MEN1 diagnosed in Peking University Shenzhen Hospital recently. Results 3 cases were diagnosed as MEN1 in a same family, and a new MEN1 gene mutation was detected by gene detection. All patients were given surgical treatment for hyperparathyroidism, and the parathyroid hormone levels were restored to normal a month later. Conclusion The diagnosis of familial MEN1 includes 3 aspects:clinical diagnosis, family history and gene diagnosis. Treatment plan requires multidisciplinary treatment options,The standard operation mode was subtotal parathyroidectomy or total parathyroidectomy plus autotransplantation for hyperparathyroidism, But there is still some controversy about early and young patients.
Keywords：multiple endocrine neoplasia type 1(MEN1)gene mutationhyperparathyroidism
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 266-270 )