Prognostic factors of medullary thyroid carcinoma:An analysis of 118 patients
Abstract：Objective To investigate prognostic factors of medullary thyroid carcinoma (MTC). Methods The clinical data of 118 consecutive patients with MTC admitted from January 2000 to November 2014 in Sun Yat-sen University Cancer Center were analyzed retrospectively. Related prognostic factors were analyzed by univariate analysis and multivariate analysis. Results The disease free survival (DFS) rate of 118 patients was 73%,and the overall survival (OS) rate of 1-year,3-year,5-year and 10-year was 97%, 95%, 94% and 89% respectively. In univariate analysis,tumor diameter,intractable diarrhea, extra thyroid extension(ETE),superior mediastinum lymph nodes (LN) metastasis,distant metastasis and recurrence were significant influencial factors of the prognosis. In multivariate analysis,intractable diarrhea,superior mediastinum LN metastasis and distant metastasis were independent prognostic factors.Although serum calcitonin (ct) level was not an independent prognostic factor,its dynamic change might predict the recurrence. Conclusion Patients with MTC accompany with intractable diarrhea,superior mediastinum LN metastasis and distant metastasis usually get a poor prognosis,should be followed up closely. Serum ct value should be measured before and after surgery, which has a considerable value to evaluate the prognosis for patients with MTC.
Keywords：medullary thyroid carcinomaprognosisfollow up
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 996-1000 )