Multi-gene testing in breast cancer and clinical significance
MA Rong
WANG Jian-li
Abstract：Multi-gene testing (MGT) can provide information that could assist prognosis prediction and therapeutic decision-making in ER-positive cancers. Recently, many MGT models have been endorsed by the American Society of Clinical Oncology, St.Gallen and National Comprehensive Cancer Network guidelines. A panel of clinically validated MGT models including IHC4 score, MammaPrint, PAM50, Oncotype DX, Genomic grade index, Breast Cancer Index, EndoPredict and homologous recombination deficiency score are seven typical MGT, which can predict the risk of metastasis and recurrence and guide the therapy of breast cancer.
Keywords：multi-gene testingbreast cancerprognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 701-703 )