Role of surgery in treatment of recurrent or metastatic gastrointestinal stromal tumor
WANG Ya-nong
ZHOU Ye
Abstract：Gastrointestinal stromal tumor (GIST) is the most common soft tissue sarcomas of the gastrointestinal tract. With the understanding of the mechanisms of GIST carcinogenesis, tyrosine kinase inhibitors (TKIs) have greatly improved the prognosis of patients with recurrent or metastatic GIST, compared to traditional surgery. However, 5% of complete response and gradually appearance of secondary tumor resistance to TKIs still encourage surgeons to evaluate the effect of TKIs combined with surgery. Surgical cytoreduction in patients with recurrent or metastatic GISTs in era of target therapy is the hot spot. The surgery in highly selected patients who have good response to TKIs should be considered fully in the multidisciplinary treatment.
Keywords：gastrointestinal stromal tumorrecurrencemetastasistarget therapysurgery
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 395-399 )