Comparison of different combined modality therapy after surgical treatment of large primary liver cancer with portal vein tumor thrombus
Abstract：Objective To study the value of surgical treatment for large primary liver cancer with portal vein tumor thrombus (PVTT) involving the main or first-order branches. Methods The clinical data of 87 large primary liver cancer patients with PVTT involving the main or first-order branches underwent hepatectomy and thrombectomy from January 2003 to December 2010 in Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology were analyzed retrospectively. The 87 patients were divided into 3 groups: group A only have hepatectomy and thrombectomy,group B have portal vein infusion chemotherapy after hepatectomy and thrombectomy,group C have transcatheter hepatic arterial chemoembolization after hepatectomy and thrombectomy. Results The 1-,2-and 3-year overall survival rates were 31.8%,12.7% and 6.4% for group A,44.7%,23.2% and 11.6% for group B and 49.0%, 27.2%and 11.7%for group C,respectively. The overall survivals were significantly better in group B and group C than group A (P=0.049,P=0.033 respectively). There was no statistical significant difference in group B and group C (P=0.751). Conclusion Surgical intervention with postoperative transcatheter hepatic arterial chemoembolization or portal vein infusion chemotherapy is more effective than surgical intervention alone in treatment for large primary liver cancer with PVTT involving the main or first-order branches. However,it still needs to be carefully chosen if PVTT extends to the main trunk.
Keywords：hepatocellular carcinomaportal vein tumor thrombushepatectomytranscatheter hepatic arterial chemoembolizationportal veininfusion chemotherapy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 757-761 )