Correlation and significance of TXR1,survivin and TSP1 expression in the tissues of gastric cancer
Abstract：Objective To explore the value and correlation of taxol resistance gene 1 (TXR1) , thrombospondin 1 (TSP1) and survivin expression in the tissues of gastric cancer. Methods The clinical data and paraffin-embedded tumor samples with stagesⅡ and Ⅲ from 95 patients received Oxaliplatin-based chemotherapy were collected. The samples were made for tissue microarrays. The expression of TXR1,TSP1 and survivin in gastric tissue was analyzed by immunohistochemistry. Results In all gastric cancer cases, the expression level of TXR1 and survivin in group of 3-year disease-free survival was significant lower than that in group of recurrence or metastasis(P<0.05). There was no correlation between protein expression level and clincopathological parameters including age, sex, lymph node metastasis, lauren classification, cell differentiation, tumor infiltration and pTNM stage. The expression of TXR1 was positively related to that of survivin, while the expression of TSP1 showed converse pattern. Conclusion Expression of TXR1 and survivin can be regarded as the index for the prognosis of gastric cancer. There is certain correlation with the expressions of TXR1,survivin and TSP1, which maybe affect the chemotherapic effect and prognosis of gastric cancer.
Keywords：gastric cancerTXR1survivinTSP1
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 649-653 )