Application of serum biomarkers in diagnosis and treatment of gastroenteropancreatic neuroendocrine neoplasm
CHEN Jie
YANG Qiu-chen
Abstract：Gastroenteropancreatic neuroendocrine neoplasm (GEP-NENs) is a heterogeneous group of tumour arising from neuroendocrine cells in the digestive system. Since regular tumor markers used in neoplasms of the digestive system are scarcely beyond normal range in GEP-NENs,together with the silent clinical manifestation at the early stage of the disease,50% of GEP-NENs patients present with advanced disease when diagnosed. Therefore,it is critical to find effective circulating biomarkers for the diagnosis of GEP-NENs,as well as to assess treatment efficacy and monitor progression. Among practical serum biomarker for GEP-NENs diagnosis and treatment,hormones secreted by functional GEP-NENs are served as specific serum markers. The non-specific"universal"biomarker chromogranin A is the most important serum marker at present,which is of great value in diagnosis and treatment of GEP-NENs.
Keywords：serum biomarkergastroenteropancreatic neuro-endocrine neoplasmchromogranin A
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 499-503 )