Selection and evaluation of diagnositic methods in gastroenteropancreatic neuroendocrine neoplasm
LI Jing-nan
QIAN Jia-ming
Abstract：The incidence of gastroenteropancreatic neuroendocrine neoplasm (GEP-NENs) is increasing in recent years. Due to complicated clinical manifestations and less specificity,the diagnosis is difficult. When the clinical symptoms are hard to explain by common diseases, GEP-NENs should be considered. Appropriate biochemical tests as well as imaging examinations should be chosen to help early diagnosis,which is important to improve prognosis. As a general used biomarker for diagnosis,Chromogrnin A has good prospective application. Elevated level of various gastrointestinal peptide hormones has good specificity for diagnosis of corresponding functional GEP-NENs,such as insulinoma,gastrinoma,etc. Regular imaging examination has poor specificity for localization diagnosis in GEP-NENs. Somatostatin receptor scintigraphy (SRSS) and special labeled PET examination have shown high specificity recently. Endoscopic ultrosonography has particular advantage for diagnosis of gastroduodenal, colon and pancreatic neuroendocrine tumor. In conclusion,as development and improvement of various diagnostic techniques,the diagnostic rate of GEP-NENs will be increased significantly.
Keywords：gastroenteropancreatic neuroendocrine neoplasmchromogrningastrointestinal hormonesomatostatin receptor scintigraphy
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 496-499 )