Management of hyperparathyroidism in patients with differentiated thyroid carcinoma:An analysis of 384 patients

Abstract：Objective To investigate the strategy of diagnosis and surgery for hyperparathyroidism in patients with differentiated thyroid carcinomas. Methods The clinical data of 384 patients with hyperparathyroidism who had underwent parathyroidectomy between January 2009 and December 2012 in Peking Union Medical College Hospital were analyzed retrospectively for coexistent differentiated thyroid carcinomas. Results All the patients were confirmed by pathology. A total of 367 patients were with primary hyperparathyroidism. The final pathological diagnoses of the parathyroid lesions included adenoma (n=286), adenocacinoma (n=14) and hyperplasia (n=84). A total of 12 patients with primary hyperparathyroidism and 1 patient with secondary hyperparathyroidism were complicated with differentiated thyroid carcinoma, which included papillary carcinoma in 12 patients and follicular carcinoma in 1 patient. Whether complicated with differentiated thyroid carcinoma and hyperparathyroidism patients’ age, gender, parathyroid pathological type was not related. Conclusion Hyperparathyroidism complicated with differentiated thyroid carcinoma is a rare condition. Routine preoperative thyroid ultrasonography and parathyroid hormone measurement may help to improve the surgical effectiveness and avoid unnecessary reoperations.