The related factors study of lymph node metastasis in 212 patients with early gastric cancer
PANG Tao
FANG Guo-en
LUO Tian-hang
GONG Mou-chun
XUE Xu-chao
Abstract：Objective To observe the relationship between clinicpathological and immunopathological features of early gastric cancer (EGC) and lymph node (LN) metastasis. Methods A retrospective study was performed on 212 EGC patients who had been treated in the Department of General Surgery of Changhai Hospital between January 2006 and December 2008. The influence of tumor size, differentiation, macroscopic type, depth of invasion as well as CAM5.2, P53, Ki-67 expression on LN metastasis were studied by t test, X~2 test and logistic regression analysis. Results Tumor macroscopic type, size, depth of invasion, differentiation were positively related to LN metastasis with P value of 0.014, 0.001, 0.012, 0.006 respectively, and the correlation coefficient were 2.213, 1.779, 4.737, 4.15 respectively. The expression of P>53, CAM5.2 were also positively related to LN metastasis, with P value and correlation coefficient were 0.001, 0.000 and 1.922, 3.632 respectively. Age, sex, tumor location, tumor number, P16, Topo Ⅱ, Ki-67 were not related to LN metastasis. Conclusion LN metastasis in EGC is mainly correlated with tumor macroscopic type, size, depth of invasion, differentiation, etc. It could evaluate the micrometastasis on the basis of CAM5.2 and P53, which should be considered when a treatment was decided.
Keywords：early gastric cancerlymph node metastasisimmunohistochemistry
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 111-113 )